introduction: infections by multidrug resistant mycobacterium tuberculosis (mdr-tb) is a major public health challenge. secretion of proteins by m. tuberculosis plays an important role in the pathogenesis of the bacterium. we compared the protein profiles of susceptible m. tuberculosis and mdr-tb isolates using proteomic analyses, namely two dimensional gel electrophoresis (2de) and mass spectr...

Background: Resistance of Mycobacterium Tuberculosis is a condition in which Anti-Tuberculosis (OAT) drugs are unable to kill the germs. One type resistance Multidrug Resistant Tuberculosis. (MDR-TB) TB caused by bacteria that resistant 2 types OAT, namely INH and Rifampin. The consequences if OAT deterioration health, increased costs, prolonged treatment, high rates therapy failure death.&#x0D...

embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.

Tuberculosis is an infectious disease caused by the germ Mycobacterium tuberculosis. The group of bacteria in addition to tuberculosis that can cause disorders airways known as MOTT (Mycobacterium Other Than Tuberculosis), which sometimes interfere with enforcement TB diagnosis and treatment. (TB) a high burden for Indonesia, not only because itself, but also its resistant several first-line dr...

background: resistance to anti-tuberculosis (tb) drugs is a global problem. previous studies showed that the prevalence of primary mdr-tb is higher and has been increasing. the purpose of this study was to determine the primary drug resistance in strains isolated from patients with smear-positive of the new cases to anti-tb drugs. methods: in this cross-sectional study, 266 smear positive pulmo...

Drug-resistant tuberculosis is a public health concern. TB that drug-resistant to rifampin and isoniazid known as MDR-TB, whereas XDR-TB MDR-TB also resistant second-line medicines, such fluoroquinolones (levofloxacin, ofloxacin, moxifloxacin). rifampin-resistant (RR-TB), of which 78 percent had multidrug-resistant (MDR-TB) (MDR-TB). Fluoroquinolones are class broad-spectrum antimicrobials have...

Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) TB. A total of 380 patients with MDR TB and 376 patients with non-MDR TB were enrolled at 23 centers in 16 countries in Europe during 2010-2011. A total of 52....

We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain...

BACKGROUND Tuberculosis continues to be one of the leading causes of death worldwide and in the American region. Although multidrug-resistant tuberculosis (MDR-TB) remains a threat to TB control in Panama, few studies have focused in typing MDR-TB strains. The aim of our study was to characterize MDR Mycobacterium tuberculosis clinical isolates using PCR-based genetic markers. METHODS From 20...